Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.

@article{Perlini2011EffectsOP,
  title={Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.},
  author={Laura E. Perlini and Francesca Botti and Eugenio F. Fornasiero and Maila Giannandrea and Dario Bonanomi and Mario Amendola and Luigi Naldini and Fabio Benfenati and Flavia Valtorta},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 21},
  pages={3643-53}
}
Synapsins are synaptic vesicle (SV)-associated proteins that regulate synaptic transmission and neuronal differentiation. At early stages, Syn I and II phosphorylation at Ser9 by cAMP-dependent protein kinase (PKA) and Ca(2+)/calmodulin-dependent protein kinase I/IV modulates axon elongation and SV-precursor dynamics. We evaluated the requirement of Syn I for synapse formation by siRNA-mediated knockdown as well as by overexpression of either its wild-type (WT) form or its phosphorylation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…