Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.

@article{Gal1991EffectsOP,
  title={Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.},
  author={L Ga{\'a}l and Christian Schudt and P{\'e}ter Ill{\'e}s},
  journal={European journal of pharmacology},
  year={1991},
  volume={202 1},
  pages={
          117-20
        }
}
Extracellular field potentials were evoked in the CA1 pyramidal cell layer of the isolated rat hippocampus by electrical stimulation of the stratum radiatum. Of the three phosphodiesterase (PDE) inhibitors, 3-isobutyl-1-methylxanthine (IBMX), zardaverine and rolipram, only the adenosine receptor antagonist, IBMX, increased the amplitudes of the extracellular excitatory postsynaptic potential (EPSP) and population spike (PS). The beta-adrenoceptor agonist, isoproterenol, also facilitated these… CONTINUE READING