Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.

  title={Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.},
  author={I. Six and J. Maizel and F. Barreto and A. Rangrez and S. Dupont and M. Slama and C. Tribouilloy and G. Choukroun and J. Mazi{\`e}re and S. Bode-B{\"o}ger and J. Kielstein and T. Dr{\"u}eke and Z. Massy},
  journal={Cardiovascular research},
  volume={96 1},
  • I. Six, J. Maizel, +10 authors Z. Massy
  • Published 2012
  • Chemistry, Medicine
  • Cardiovascular research
  • AIMS Increased serum phosphorus levels are associated with cardiovascular disease in patients with chronic kidney disease (CKD) and in the general population. High phosphate levels may play a direct role in vascular dysfunction. We investigated here the effects of phosphate loading and of the phosphate binder sevelamer-HCl on vascular function. METHODS AND RESULTS CKD and non-CKD C57/BL6 mice were used to study the effects of CKD, phosphate, and sevelamer-HCl on vascular function and… CONTINUE READING
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