Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.

@article{Six2012EffectsOP,
  title={Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.},
  author={Isabelle Six and Julien Maizel and Fellype de Carvalho Barreto and Ashraf Yusuf Rangrez and S{\'e}bastien Dupont and Michel Slama and Christophe Tribouilloy and Gabriel Choukroun and Jean Claude Mazi{\`e}re and Stefanie Margarethe Bode-B{\"o}ger and Jan T Kielstein and Tilman B. Dr{\"u}eke and Ziad A Massy},
  journal={Cardiovascular research},
  year={2012},
  volume={96 1},
  pages={
          130-9
        }
}
AIMS Increased serum phosphorus levels are associated with cardiovascular disease in patients with chronic kidney disease (CKD) and in the general population. High phosphate levels may play a direct role in vascular dysfunction. We investigated here the effects of phosphate loading and of the phosphate binder sevelamer-HCl on vascular function. METHODS AND RESULTS CKD and non-CKD C57/BL6 mice were used to study the effects of CKD, phosphate, and sevelamer-HCl on vascular function and… CONTINUE READING
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