• DOI:10.1093/cvr/cvs240
Corpus ID: 5160110

Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.

@article{Six2012EffectsOP,
  title={Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.},
  author={I. Six and J. Maizel and F. Barreto and A. Rangrez and S. Dupont and M. Slama and C. Tribouilloy and G. Choukroun and J. Mazi{\`e}re and S. Bode-B{\"o}ger and J. Kielstein and T. Dr{\"u}eke and Z. Massy},
  journal={Cardiovascular research},
  year={2012},
  volume={96 1},
  pages={
          130-9
        }
}

I. Six, J. Maizel, +10 authors Z. Massy

Published 2012

Chemistry, Medicine

Cardiovascular research

AIMS Increased serum phosphorus levels are associated with cardiovascular disease in patients with chronic kidney disease (CKD) and in the general population. High phosphate levels may play a direct role in vascular dysfunction. We investigated here the effects of phosphate loading and of the phosphate binder sevelamer-HCl on vascular function. METHODS AND RESULTS CKD and non-CKD C57/BL6 mice were used to study the effects of CKD, phosphate, and sevelamer-HCl on vascular function and… CONTINUE READING

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