Effects of pholcodine and salbutamol on citric acid induced cough in normal subjects.

@article{Belcher1986EffectsOP,
  title={Effects of pholcodine and salbutamol on citric acid induced cough in normal subjects.},
  author={N G Belcher and P. John Rees},
  journal={Thorax},
  year={1986},
  volume={41},
  pages={74 - 75}
}
Cough may be the presenting feature ofasthma in adults and children.12 Treatments for asthma, such as f stimulant drugs, are known to be effective in controlling the symptom.1 Ellul-Micaleff demonstrated the efficacy of oral terbutaline sulphate in a double blind, placebo controlled crossover study of 30 patients with chronic "allergic" cough.3 In whooping cough. inhaled salbutamol has been found to reduce the frequency and intensity of the whoop but not the cough.4 In contrast, Pavesio and… 
Inhibition of artificially induced cough in man by bronchodilators.
TLDR
Small reductions in airway tone are associated with a reduced cough response elicited by inhaled ultrasonically nebulized distilled water.
A physiological model of the human cough reflex : investigations of the afferent pathway and antitussive studies.
TLDR
Investigation of the chemosensitivity of this response identified that extremes of pH, a chloride concentration below 75mmol/l, but not changes in osmolarity induce cough which reflects afferent rapidly adapting recep~or sensitivity in animal studies.
Effects of inhaled budesonide on spirometric values, reversibility, airway responsiveness, and cough threshold in smokers with chronic obstructive lung disease.
TLDR
There was a significant reduction in dyspnoea in the budesonide group, but otherwise no change in symptom scores or use of ipratropium bromide over the eight weeks of treatment within or between the two groups.
Citric acid cough threshold and airway responsiveness in asthmatic patients and smokers with chronic airflow obstruction.
TLDR
Sensory nerves can be activated with a tussive agent in patients with asthma and chronic airflow obstruction without causing bronchial smooth muscle contraction.
Inhaled corticosteroids for non-specific chronic cough in children.
TLDR
There might be a small improvement with very high-dose inhaled corticosteroid but the clinical impact of this is unlikely to beneficial and a significant but smaller improvement was also seen with placebo.
Inhaled beta2‐agonists for non‐specific chronic cough in children
TLDR
Salbutamol was no different from placebo in reducing the frequency of cough measured objectively or scored subjectively and the effectiveness of inhaled ss2 agonists in non-specific chronic cough was determined.
Cough frequency and cough receptor sensitivity to citric acid challenge during a simulated ascent to extreme altitude.
TLDR
An increase in cough frequency and cough receptor sensitivity associated with hypobaric hypoxia is confirmed, and the hypothesis that high altitude cough is due to the inhalation of cold, dry air is refuted.
Current and future centrally acting antitussives
  • D. Bolser
  • Medicine
    Respiratory Physiology & Neurobiology
  • 2006
TLDR
It is proposed that sensory afferents from different regions of the airways actuate coughing in humans by antitussive sensitive and insensitive control elements in the central nervous system, consistent with results from an animal model in which laryngeal and tracheobronchial cough had different sensitivities to codeine.
Altitude-related cough.
TLDR
It is hypothesize that there are two forms of altitude-related cough: a cough which may occur at relatively low altitudes and which is related to exercise and persists despite descent and a coughing which does not occur at altitudes below 5000-6000 m and which improves rapidly with descent to lower altitude.
Mechanisms of altitude-related cough
TLDR
This work demonstrated an increase in clinical cough and a reduction in the citric acid cough threshold at extreme altitude, despite controlled environmental conditions, and refuted the long held belief that altitude-related cough is solely due to the inspiration of cold, dry air.
...
1
2
...

References

SHOWING 1-10 OF 15 REFERENCES
Effect of terbutaline sulphate in chronic "allergic" cough.
TLDR
Both day and night cough scores and peak expiratory flow rates were significantly improved by the end of the first week of treatment with terbutaline and this improvement was achieved with only a fairly small change in airway calibre.
Assessment of antitussive effects by citric acid threshold.
TLDR
It is concluded that the citric acid threshold is a simple measure of antitussive activity and no such activity was found with glaucine.
Further studies on the evaluation of antitussive agents employing experimentally induced cough in human subiects
The feasibility of employing experimental cough induced by eitric acid aerosols as a quantitative method for assessing antitussive activity is confirmed in this study. Thirteen coded drugs were
Chronic cough as the sole presenting manifestation of bronchial asthma.
TLDR
Six patients with chronic cough appear to have a variant form of asthma in which the only presenting symptom is cough, as demonstrated with methacholine, and maintenance therapy with bronchodilators promptly eliminated the cough in all patients.
EFFICACY OF SALBUTAMOL IN TREATMENT OF INFANT PERTUSSIS DEMONSTRATED BY SOUND SPECTRUM ANALYSIS
TLDR
The value of sound spectrum analysis (sonography) as an indicator of the severity of symptomatic pertussis was assessed in four infants aged 3 weeks to 5 months and seemed to relieve the laryngeal spasms and consequently eased the infant's breathing difficulties.
Preclinical and Clinical Investigation of Drugs II. Antitussive Drugs
TLDR
A review of the literature on antitussives has revealed a series of observations which are not in conformity with the above simple thesis of an action of antitussive drugs on the central nervous system (CNS).
Cough variant asthma in children.
TLDR
Thirty-two patients referred for evaluation of chronic cough represent a variety of asthma in which the presenting manifestation is cough and demonstrate that cough variant asthma is a distinct but frequently unrecognized entity in children.
Effect of bron
  • 1984
Effect of bronchodilators on the cough response to citric acid in normal subjects and asthmatics
  • Thorax
  • 1984
Effect of bronchodilators on the cough response to citric acid in normal subjects and asthmatics [ abstract ]
  • Thorax
  • 1984
...
1
2
...