Effects of phenyl-2-aminoethyl sulfide, a novel dopamine-beta-hydroxylase substrate, on the cardiovascular system of the anesthetized dog.

@article{Herman1983EffectsOP,
  title={Effects of phenyl-2-aminoethyl sulfide, a novel dopamine-beta-hydroxylase substrate, on the cardiovascular system of the anesthetized dog.},
  author={Harry H. Herman and Stanley H. Pollock and Steven R. Padgette and Julie R. Lange and Jeong Hee Han and Sheldon W. May},
  journal={Journal of cardiovascular pharmacology},
  year={1983},
  volume={5 5},
  pages={725-30}
}
In previous work we have established that phenyl-2-aminoethyl sulfide (PAES) is a novel substrate for dopamine-beta-hydroxylase (DBH) which is stereospecifically oxygenated by the enzyme to the corresponding sulfoxide, (S)-phenyl-2-aminoethyl sulfoxide (PAESO). We now report that PAES possesses very little, if any, direct adrenergic agonist activity, but… CONTINUE READING