Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.

  title={Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.},
  author={Eino Hietanen and Kaija Linnainmaa and Harri Vainio},
  journal={Acta pharmacologica et toxicologica},
  volume={53 2},
The effects of phenoxyacid herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and MCPA (4-chloro-2-methylphenoxyacetic acid), clofibrate, and glyphosate on hepatic and intestinal drug metabolizing enzyme activities were studied in rats intragastrically exposed for 2 weeks. The hepatic ethoxycoumarin O-deethylase activity increased about 2-fold with MCPA. Both 2,4-D and MCPA increased the hepatic epoxide hydrolase activity and decreased the hepatic glutathione S-transferase activity. MCPA also… 

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