Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.

@article{Hietanen1983EffectsOP,
  title={Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.},
  author={Eino Hietanen and Kaija Linnainmaa and Harri Vainio},
  journal={Acta pharmacologica et toxicologica},
  year={1983},
  volume={53 2},
  pages={
          103-12
        }
}
The effects of phenoxyacid herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and MCPA (4-chloro-2-methylphenoxyacetic acid), clofibrate, and glyphosate on hepatic and intestinal drug metabolizing enzyme activities were studied in rats intragastrically exposed for 2 weeks. The hepatic ethoxycoumarin O-deethylase activity increased about 2-fold with MCPA. Both 2,4-D and MCPA increased the hepatic epoxide hydrolase activity and decreased the hepatic glutathione S-transferase activity. MCPA also… 

Figures and Tables from this paper

Effects of phenoxyacetic acid herbicides on chicken embryo liver drug metabolizing enzymes.
TLDR
Biliary retention, produced in particular by MCPA, could be partly responsible for these effects and some effects on hepatic drug metabolizing enzymes of the chick embryo which cannot be easily interpreted.
Induction of rat hepatic drug metabolizing enzymes by substituted urea herbicides.
TLDR
The results indicate that chemical structure of the related substituted urea compounds, the number of halogen substituents on their phenyl group exert a strong influence on the induction of monooxygenases.
Effects of ethyl 4-chloro-2-methylphenoxyacetate on bile composition in golden hamsters.
  • N. Inomata
  • Chemistry, Biology
    The Tohoku journal of experimental medicine
  • 1992
TLDR
Exposure to MCPA could be a risk factor for gallbladder cancer, which was initiated with some chemical carcinogens, because it increased the levels and proportions of both cholesterol and secondary bile acids in bile.
The profile of rat liver enzyme induction produced by prochloraz and its major metabolites.
TLDR
The induction profile of prochloraz was of a mixed type, but the predominant characteristics were those of phenobarbitone induction.
Effects of Sublethal Exposure to a Glyphosate-Based Herbicide Formulation on Metabolic Activities of Different Xenobiotic-Metabolizing Enzymes in Rats
TLDR
This research demonstrated certain biochemical modifications after exposure to a GLP-based herbicide that may affect the metabolic fate of different endobiotic and xenobiotic substances.
Effects of Ethyl 4-Chloro-2-Methylphenoxyacetate Composition in Golden Hamsters
TLDR
The results indicate that MCPA and clofibrate may affect cholesterol catabolism differently, although these two compounds contain the same chlorinated phenoxy acid moiety.
Effects of ethyl 4-chloro-2-methylphenoxyacetate on hepatic peroxisomal enzymes in rats.
Effects of ethyl 4-chloro-2-methylphenoxyacetate (MCPA) and clofibrate on the activities of hepatic lipid metabolizing enzymes in the peroxisomal fraction from rat liver were studied, and these drugs
Effects of Glyphosate on Enzyme Activity and Serum Glucose in Rats Rattus norvegicus
TLDR
It was observed that glyphosate led to a statistically significant decrease of serum glucose level, and AST, ALT and LDH activities are indicators of hepatocyte damage while LDH activity demonstrates damage of other tissues.
...
...

References

SHOWING 1-10 OF 55 REFERENCES
Differences in the response of hepatic and intestinal drug metabolizing enzymes in rats following carbon tetrachloride and/or phenobarbital treatment.
TLDR
The results support the view that epoxide hydratase and UDPglucuronosyltransferase enzymes occupy different locations in the endosplasmic reticulum of intestinal mucosa than of liver.
Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).
TLDR
The molecular weights and spectral properties of these cytochrome P-450 fractions are reported, along with the phenobarbitone-induced form of the enzyme and the nature of the cytochromes induced by clofibrate pretreatment are discussed in the terms of possible haemoprotein heterogeneity.
Human urinary excretion of the herbicide 2-methyl-4-chloropheno xyacetic acid.
To see if urinary 2-methyl-4-chlorophenoxyacetic acid (MCPA) excretion could be used to estimate MCPA exposure, four healthy males ingested 5 mg MCPA. The MCPA in the urine was extracted and anlyzed
Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
TLDR
The development of liver tumours, in animals fed five structually diverse hypolipidaemic compounds, supports the hypothesis that potent hepatic peroxisome proliferators as a class are carcinogenic.
Metabolism of 2,5-diphenyloxazole (PPO) by trout liver microsomal mixed function monooxygenase.
  • J. Ahokas
  • Biology, Chemistry
    Research communications in chemical pathology and pharmacology
  • 1976
TLDR
Optimum assay conditions have been established for the metabolism of PPO by trout liver microsomes and the metabolism was strongly inhibited by alpha-naphthoflavone, but much less markedly by SKF 525 A or metyrapone.
...
...