Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic acid decarboxylase (GAD67 and GAD65), the GABA transporter GAT-1 and GABA transaminase in rat cortex

@article{Lai1997EffectsOP,
  title={Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic acid decarboxylase (GAD67 and GAD65), the GABA transporter GAT-1 and GABA transaminase in rat cortex},
  author={Chien-Tsai Lai and V{\'e}ronique A.-M. I. Tanay and Gregory J. R. Charrois and Glen B Baker and Alan N. Bateson},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={357},
  pages={32-38}
}
There is an increasing body of evidence suggesting that GABA plays an important role in the therapeutic effects of antidepressant/antipanic drugs. Phenelzine and imipramine are efficacious in the treatment of depression and panic disorder and phenelzine has been reported to elevate GABA levels while imipramine enhances GABA release in rat brains. In the present study, using a multiprobe quantitative solution hybridization assay, we measured the steady-state levels of mRNAs that encode glutamic… CONTINUE READING