Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaque

@article{Javitt2001EffectsOP,
  title={Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaque},
  author={D. C. Javitt and Robert W. Lindsley},
  journal={Psychopharmacology},
  year={2001},
  volume={156},
  pages={165-168}
}
Rationale: Prepulse inhibition (PPI) of the acoustic startle response (ASR) provides an index of neurophysiological dysfunction in schizophrenia and a method for analyzing underlying neurochemical mechanisms. In rodents, phencyclidine (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce schizophrenia-like PPI deficits. Similar effects have recently been observed in a New World monkey species, Cebus apella. Objectives: The present study evaluates the degree to which similar… CONTINUE READING