Effects of phencyclidine and its derivatives on enteric neurones.


The effects of N-(1-phenylcyclohexyl) piperidine (PCP) and related drugs on isolated intact segments of the guinea-pig ileum were determined. 1-1-(2-Thienyl) cyclohexylpiperidine (TCP), PCP and ketamine decreased the height of electrically induced contractions (0.1 Hz) of intact segments of isolated guinea-pig ileum. Thirty to forty percent of the… (More)


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