Effects of pharmacological suppression of plasminogen activator inhibitor-1 in myocardial remodeling after ischemia reperfusion injury.

@article{Watanabe2011EffectsOP,
  title={Effects of pharmacological suppression of plasminogen activator inhibitor-1 in myocardial remodeling after ischemia reperfusion injury.},
  author={Ryo Watanabe and Takuya Nakajima and Masahito Ogawa and Jun-Ichi Suzuki and Susumu Muto and Akiko Itai and Yasunobu Hirata and Ryozo Nagai and Mitsuaki Isobe},
  journal={International heart journal},
  year={2011},
  volume={52 6},
  pages={388-92}
}
Plasminogen activator inhibitor-1 (PAI-1) contributes to cardiac ventricular remodeling because migration of inflammatory cells and attenuation of extracellular matrix degradation are caused by plasmin and matrix metalloproteinase. However, the roles of PAI-1 in myocardial ischemia reperfusion (I/R) injury and the following inflammatory response have not yet been well elucidated. To clarify the role of PAI-1 in myocardial I/R injury, we used a specific PAI-1 inhibitor (IMD-1622) in a rat model… CONTINUE READING