Effects of pesticides used in agriculture on the development of precocious puberty

@article{Ozen2011EffectsOP,
  title={Effects of pesticides used in agriculture on the development of precocious puberty},
  author={Samim Ozen and Sukran Darcan and Petek Bayındır and Ercument Karasulu and Damla Goksen Simsek and Tahir Gurler},
  journal={Environmental Monitoring and Assessment},
  year={2011},
  volume={184},
  pages={4223-4232}
}
The present study aims to evaluate the effects of pesticides on premature breast development. Forty-five girls (group 1) with premature breast development living in the Menderes region, where greenhouse cultivation is the main income, 16 girls (group 2) living in Izmir city with early puberty, and 33 girls (group 3) who had no signs of puberty were included in the study. Endosulphan 1, endosulphan 2, endosulphan sulphate, methoxychlor, vinclozolin, 4,4-dichlorodiphenyldichlorethylene (DDE), 4… Expand
Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study
TLDR
The results showed no relationship between agricultural pesticides and the development of precocious puberty, and larger sample sizes and robustly controlled variables are necessary to further investigate this topic. Expand
Organochlorine pesticides and female puberty in South Kazakhstan.
TLDR
The research established a correlation between the concentration of pesticides and the endocrine status, as well as with the insulin-like growth factor 1, which shows the adverse effect of organochlorine pesticides on the development of the female reproductive system during puberty. Expand
The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature
TLDR
The currently available data do not allow establishment of a clear role for BPA in pubertal development because of the conflicting results among all clinical and epidemiological studies examined. Expand
Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil.
TLDR
Exposure to the most prevalent organochlorine compounds described in literature was confirmed in the study, indicating that pp'DDE may adversely influence female fertility. Expand
Agricultural pesticides and precocious puberty.
TLDR
The effects of pesticides, which constitute a significant portion of disruptors and have been increasingly used in agriculture, on precocious puberty are discussed. Expand
A systematic review on the effects of environmental exposure to some organohalogens and phthalates on early puberty
TLDR
It can be concluded that organohalogens and phthalates are disturbing the normal process of puberty timing; especially their influence on early maturation in girls should be underscored. Expand
Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay.
TLDR
This study showed that no androgenic activity was present in PM10 and that although the median estrogenic activitywas rather low and comparable in the three locations, high fluctuations in estrogenic response exist over time. Expand
Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (p,p’-DDE) with Testosterone Levels in Adolescent Males
TLDR
Exposure to PCBs, particularly the more highly persistent congeners, may negatively influence testosterone levels among adolescent males, and the positive relationship between p,p´-DDE and testosterone indicates that not all POPs act similarly. Expand
Environmental Hazards and Health Impacts of Organochlorine Pesticides (OCPs) qua POPs in Benin’s Cotton Basin
Organochlorine pesticides (OCPs) are chemical compound classes based on carbon, classified persistent organic pollutants (POPs), and produced for agricultural purposes. OCPs are used in theExpand
Endocrine disrupting effects of dichlorodiphenyltrichloroethane analogues on gonadotropin hormones in pituitary gonadotrope cells.
TLDR
This study showed for the first time that p,p'-DDT and MXC regulated gonadotropin genes expression and hormones synthesis through ERK pathway in gonadotrope cells. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 66 REFERENCES
Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development.
TLDR
A possible association between plasticizers with known estrogenic and antiandrogenic activity and the cause of premature breast development in a human female population is suggested. Expand
Endocrine disrupters and human puberty.
TLDR
In this overview of the literature, epidemiological research studying the effect of endocrine disrupters on the onset of puberty is summarized and the mixture of different components with antagonistic effects and the limited knowledge about the most critical window for exposure may hamper the interpretation of results. Expand
Reproductive evaluation of two pesticides combined (deltamethrin and endosulfan) in female rats.
TLDR
Results suggest that administration of D+E does not pose a reproductive hazard to female rats exposed during critical periods of development, indicating that the combination does not exert estrogen-like effects in vivo or is not delivered to target organs. Expand
Endocrine disruptors and abnormalities of pubertal development.
TLDR
There is increasing evidence for a link between prenatal development and pubertal onset, and the causal pathways and the molecular mechanisms that may link the Pubertal growth pattern of children born SGA, puberal development and endocrine-disrupting chemicals need further study. Expand
Endocrine disrupters and female reproductive health.
TLDR
New studies provide a mechanism of action for estrogenic chemicals and other endocrine disrupters at the molecular level (called epigenetics) that may help explain the long-term effects of endocrine disruption. Expand
A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat.
  • L. Gray, J. Ostby, +6 authors J. Laskey
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1989
TLDR
Endocrine function of the testes and pituitary was altered by methoxychlor administration and testicular sperm production, sperm morphology, and motility were unaffected, and the fertility of treated males was not reduced when they were mated with untreated females. Expand
Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides
TLDR
A possible relationship between transient exposure to endocrine disrupters and sexual precocity is suggested, and deserves further studies in immigrant children with non‐advanced puberty. Expand
Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life.
TLDR
It is demonstrated that perinatal dietary exposure to EDCs for a limited period causes endocrine disruption in offspring only at high doses. Expand
In Utero Exposure to Bisphenol A Alters the Development and Tissue Organization of the Mouse Mammary Gland1
TLDR
Changes in histoarchitecture of mammary glands of BPA-exposed mice resemble those of early pregnancy, and they suggest a disruption of the hypothalamic-pituitary-ovarian axis and/or misexpression of developmental genes. Expand
Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor.
TLDR
Although this assay did not detect TL or lower doses of E2 (0.1 mg/kg) or KETO (< or = 50mg/kg), it was capable of detecting EDs operating through a variety of mechanisms. Expand
...
1
2
3
4
5
...