• DOI:10.1152/AJPREGU.00529.2002
Corpus ID: 5242365

Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats.

@article{Reidelberger2003EffectsOP,
  title={Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats.},
  author={R. Reidelberger and Dean G. Heimann and L. Kelsey and M. Hulce},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 2},
  pages={
          R389-98
        }
}

R. Reidelberger, Dean G. Heimann, +1 author M. Hulce

Published 2003

Biology, Medicine

American journal of physiology. Regulatory, integrative and comparative physiology

Type A cholecystokinin receptor (CCKAR) antagonists differing in blood-brain barrier permeability were used to test the hypothesis that duodenal delivery of protein, carbohydrate, and fat produces satiety in part by an essential CCK action at CCKARs located peripheral to the blood-brain barrier. Fasted rats with open gastric fistulas received devazepide (1 mg/kg iv) or A-70104 (700 nmol. kg(-1). h(-1) iv) and either a 30-min intravenous infusion of CCK-8 (10 nmol. kg(-1). h(-1)) or duodenal… CONTINUE READING

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