Effects of peripheral CCK receptor blockade on gastric emptying in rats.

@article{Reidelberger2003EffectsOP,
  title={Effects of peripheral CCK receptor blockade on gastric emptying in rats.},
  author={R. Reidelberger and L. Kelsey and Dean G. Heimann and M. Hulce},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 1},
  pages={
          R66-75
        }
}
  • R. Reidelberger, L. Kelsey, +1 author M. Hulce
  • Published 2003
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • Type A CCK receptor (CCKAR) antagonists differing in blood-brain barrier permeability [devazepide penetrates; the dicyclohexylammonium salt of Nalpha-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-70104) does not] were used to test the hypothesis that duodenal nutrient-induced inhibition of gastric emptying is mediated by CCKARs located peripheral to the blood-brain barrier. Rats received A-70104 (700 or 3,000 nmol. kg(-1). h(-1) iv) or devazepide (2.5 micromol/kg iv) and either a 15-min intravenous… CONTINUE READING
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