Effects of periodate and chondroitin 4-sulfate on proteoglycan stabilization of ostrich pericardium. Inhibition of calcification in subcutaneous implants in rats.

@article{Arenaz2004EffectsOP,
  title={Effects of periodate and chondroitin 4-sulfate on proteoglycan stabilization of ostrich pericardium. Inhibition of calcification in subcutaneous implants in rats.},
  author={Beatriz Fuentes Arenaz and Marian Mart{\'i}n Maestro and P. Th. Fernandez and Javier Turnay and Nieves Olmo and Jes{\'u}s Sen{\'e}n and Javier Gil Mur and Mar{\'i}a Antonia Lizarbe and Eduardo Jorge-Herrero},
  journal={Biomaterials},
  year={2004},
  volume={25 17},
  pages={3359-68}
}
Chemical modification of biological materials used in the manufacture of cardiac valves tends to reduce the relatively high degree of biodegradation and calcification of the implanted bioprostheses. The most widely used treatment to reduce biodegradability of the valves is glutaraldehyde fixation. However, this treatment is potentially toxic and induces tissue calcification. In order to minimize these undesirable effects, we have analyzed the effect of a pre-fixation of endogenous proteoglycans… CONTINUE READING