Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups.

@article{Szabo2009EffectsOP,
  title={Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups.},
  author={David T. Szabo and Vicki M Richardson and David G Ross and Janet J. Diliberto and Prasada Rao S. Kodavanti and Linda S Birnbaum},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={107 1},
  pages={27-39}
}
Previous studies demonstrated that perinatal exposure to polybrominated diphenyl ethers (PBDEs), a major class of brominated flame retardants, may affect thyroid hormone (TH) concentrations by inducing hepatic uridinediphosphate-glucoronosyltransferases (UGTs). This study further examines effects of the commercial penta mixture, DE-71, on genes related to TH metabolism at different developmental time points in male rats. DE-71 is predominately composed of PBDE congeners 47, 99, 100, 153, 154… CONTINUE READING