Effects of perfusion pressure on intracellular calcium, energetics, and function in perfused rat hearts.

@article{Kojima1993EffectsOP,
  title={Effects of perfusion pressure on intracellular calcium, energetics, and function in perfused rat hearts.},
  author={Sunao Kojima and Shao T. Wu and Thomas A. Watters and William W. Parmley and Joan Wikman-Coffelt},
  journal={The American journal of physiology},
  year={1993},
  volume={264 1 Pt 2},
  pages={H183-9}
}
Effects of perfusion pressure in a range from 50 to 140 cmH2O on intracellular Ca2+ concentration ([Ca2+]i) were evaluated along with cardiac function, energy metabolism, and left ventricular geometry in a concentration of 2 or 4 mM of extracellular Ca2+ ([Ca2+]o) in isovolumic perfused rat hearts. [Ca2+]i was evaluated with a surface fluorometry technique in hearts loaded with indo-1/AM. The systolic and diastolic values and the amplitude (difference between systolic and diastolic values) of… CONTINUE READING