Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis

  title={Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis},
  author={Qinqin Lou and Yinfeng Zhang and Zhen Zhou and Ya-Li Shi and Yaming Ge and Dongkai Ren and Hai Xu and Yaxian Zhao and Wuji Wei and Zhanfen Qin},
Perfluorobutanesulfonate (PFBS), as a substitute for perfluorooctanesulfonate (PFOS), is widespread in the environment and biotic samples as well as PFOS. [] Key Method To investigate effects of PFOS and PFBS on the growth and sexual development of amphibians, we exposed Xenopus laevis tadpoles at a series of concentrations of PFOS and PFBS (0.1; 1; 100; 1,000 μg/l) as well as 17-beta-estradiol (E2, 100 ng/l) and 5 alpha-androstan-17-beta-ol-3-one (DHT, 100 ng/l) from stage 46/47 to 2 months…

Effect of perfluorooctanesulfonate exposure on steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis

The impact of the perfluoro‐chemical, perfluorooctanesulfonate (PFOS), on gonadal steroidogenesis during sexual differentiation in Silurana tropicalis was examined because of its ubiquity in the

Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.

It was shown that PFBS life-cycle exposure at environmentally realistic concentrations skewed the sex ratio in fish toward male dominance, while reproductive functions of female fish were greatly impaired, as characterized by extremely small ovaries, blocked oocyte development, and decreased egg production.



Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life‐cycle test with the fathead minnow (Pimephales promelas)

Water and tissue concentrations of PFOS associated with effects in this study exceeded those reported for samples collected from the field by two to three orders of magnitude, suggesting that the current risk ofPFOS on aspects of fish reproduction and development assessed would be small.

The Applicability of Biomonitoring Data for Perfluorooctanesulfonate to the Environmental Public Health Continuum

Animal studies indicate that PFOS is well absorbed orally and distributes mainly in blood serum and the liver, and there is a steep dose response for mortality in sexually mature rats and primates as well as in neonatal rats and mice exposed in utero.

Toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid on freshwater macroinvertebrates (Daphnia magna and Moina macrocopa) and fish (Oryzias latipes)

Two-generation fish toxicity tests showed that parental exposure to both compounds affected the performance of offspring, and more research is required to determine potential consequences of long-term exposure to these compounds in aquatic ecosystems.

Acute and Chronic Effects of Perfluorobutane Sulfonate (PFBS) on the Mallard and Northern Bobwhite Quail

Concentrations of PFBS in blood serum, liver, and eggs were dose-dependent but were less than the administered dose, indicating biodiminution.

Effects of 4-tert-octylphenol on Xenopus tropicalis in a long term exposure.

A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans.