Effects of peptide leukotrienes on cardiac dynamics in rat, cat, and guinea pig hearts.

@article{Roth1985EffectsOP,
  title={Effects of peptide leukotrienes on cardiac dynamics in rat, cat, and guinea pig hearts.},
  author={David M Roth and David Joseph Lefer and Carl E. Hock and Allan M. Lefer},
  journal={The American journal of physiology},
  year={1985},
  volume={249 3 Pt 2},
  pages={H477-84}
}
The purpose of the present investigation was to examine potential inotropic effects of leukotrienes C4 (LTC4) and D4 (LTD4) in relation to their potent coronary constricting effects. The experiments were carried out in isolated Langendorff perfused hearts and isolated electrically driven isometrically contracting papillary muscle preparations. Tissues from cat, rat, and guinea pig were used in the study. Both LTC4 and LTD4 at 50 ng/ml had no effect on papillary muscles isolated from the rat… CONTINUE READING
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