Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin.

@article{Marceau1994EffectsOP,
  title={Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin.},
  author={François Marceau and L. Levesque and Guy Drapeau and Frank Rioux and Joseph M. Salvino and Henry R Wolfe and Peter R. Seoane and D G Sawutz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 3},
  pages={1136-43}
}
The isolated rabbit jugular and human umbilical veins respond to bradykinin (BK) by contractions that are mediated by the BK B2 type receptors. In this report, the pharmacology of recently developed BK B2 receptor antagonists is assessed by using these preparations. The nonpeptide kinin antagonist WIN 64338 (phosphonium, [[4-[[2-[[bis(cyclohexylamino)methylene]amino]- 3-(2-naphthalenyl)-1-oxopropyl]amino]phenyl]methyl]tributyl chloride monohydrochloride) demonstrates competitive and… CONTINUE READING
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