Effects of pentoxifylline on Wnt/β-catenin signaling in mice chronically exposed to cigarette smoke.

@article{Wang2010EffectsOP,
  title={Effects of pentoxifylline on Wnt/β-catenin signaling in mice chronically exposed to cigarette smoke.},
  author={Zheng Wang and Jin-nong Zhang and Xiao-Fei Hu and Xue-lin Chen and Xiaorong Wang and Ting-ting Zhao and Mei-jun Peng and Ping Zou},
  journal={Chinese medical journal},
  year={2010},
  volume={123 19},
  pages={2688-94}
}
BACKGROUND Previous discovery that long-term administration of pentoxifylline (PTX) to mice chronically exposed to smoke led to the development of pulmonary fibrosis rather than emphysema initiated our curiosity on whether the Wnt/β-catenin pathway, a set of signaling proteins essential to organ development and lung morphogenesis in particular were activated in the pathogenesis of pulmonary fibrosis. METHODS Male BALB/c mice were randomized into four study groups: Group Sm, smoke exposure and… CONTINUE READING

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