Effects of pentoxifylline and nabumetone on the serum levels of IL-1β and TNFα in rats with adjuvant arthritis

@article{Silva2000EffectsOP,
  title={Effects of pentoxifylline and nabumetone on the serum levels of IL-1β and TNFα in rats with adjuvant arthritis},
  author={Jos{\'e} Robalo Silva and Marcos F Rocha and Aldo {\^A}ngelo Moreira Lima and Gerly Anne de Castro Brito and Dalgimar Beserra de Menezes and Vietla Satyanarayana Rao},
  journal={Inflammation Research},
  year={2000},
  volume={49},
  pages={14-19}
}
Objective and Design: This study examined whether serum levels of cytokines, IL-1β and TNFα were elevated in rats with adjuvant arthritis in relation to disease progression, and if so, to verify the treatment effects of nabumetone (20 mg/kg, p.o.), a COX-2 inhibitor and pentoxifylline (20 mg/kg, p.o.), a type-4 phosphodiesterase (PDE4) inhibitor, alone or in combination.¶Materials and Methods: Female Wistar rats were used. Freund's complete adjuvant (FCA) was used to induce arthritis. The… CONTINUE READING

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