Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.

@article{Armaan2015EffectsOP,
  title={Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.},
  author={I. Armağan and D. Bayram and I. A. Candan and A. Yiğit and E. Celik and H. Armağan and A. C. Uğuz},
  journal={Environmental toxicology and pharmacology},
  year={2015},
  volume={39 3},
  pages={
          1122-31
        }
}
The aim of the current study was to investigate the probable protective effects of Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy against hepatotoxicity and nephrotoxicity, those being the major side effects of Methotrexate (MTX). Rats were divided into four groups: a control group; MTX (20mg/kg/day) group; MTX+PTX (20mg/kg/day+50mg/kg/day) group; and an MTX+ALA (20mg/kg/day+100mg/kg/day) group. At the end of the experiment, biochemical, histochemical… Expand
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