Effects of pedunculopontine tegmental nucleus lesions on responding for intravenous heroin under different schedules of reinforcement.

@article{Olmstead1998EffectsOP,
  title={Effects of pedunculopontine tegmental nucleus lesions on responding for intravenous heroin under different schedules of reinforcement.},
  author={Mary C Olmstead and Elizabeth M Munn and Keith B. J. Franklin and Roy Wise},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 13},
  pages={5035-44}
}
The pedunculopontine tegmental nucleus (PPTg) is believed to play important roles in reward and learning. We examined the effect of PPTg lesions (0.5 microl of 0.1 M NMDA injected bilaterally over 10 min) on the learning of an operant response for opiate reward. In 14 adult male Long-Evans rats, bilateral lesions of the PPTg disrupted the acquisition of responding for intravenous heroin (0.1 mg/kg infused at a rate of 0.25 ml/28 sec) on a fixed ratio-1 (FR-1) schedule of reinforcement. The 12… CONTINUE READING

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