Effects of pargyline and SKF-525A on brain N,N-dimethyltryptamine concentrations and hyperactivity in mice

@article{Morinan2004EffectsOP,
  title={Effects of pargyline and SKF-525A on brain N,N-dimethyltryptamine concentrations and hyperactivity in mice},
  author={A. Morinan and J. Collier},
  journal={Psychopharmacology},
  year={2004},
  volume={75},
  pages={179-183}
}
Mice pretreated with the monoamine oxidase inhibitor pargyline showed a dose-dependent increase in hyperactivity for up to 2 h following injections of N,N-dimethyltryptamine (DMT: 0.5–8.0 mg/kg). Hyperactivity was related to a linear increase in whole brain concentrations of DMT as measured by a new sensitive gas chromatographic assay. The duration of this behaviour paralleled the concentration of DMT in the brain from 15–120 min. However, at 15 min, there was no significant difference in brain… Expand

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