Effects of pargyline and SKF-525A on brain N,N-dimethyltryptamine concentrations and hyperactivity in mice

@article{Morinan2004EffectsOP,
  title={Effects of pargyline and SKF-525A on brain N,N-dimethyltryptamine concentrations and hyperactivity in mice},
  author={Alun Morinan and J. G. Collier},
  journal={Psychopharmacology},
  year={2004},
  volume={75},
  pages={179-183}
}
Mice pretreated with the monoamine oxidase inhibitor pargyline showed a dose-dependent increase in hyperactivity for up to 2 h following injections of N,N-dimethyltryptamine (DMT: 0.5–8.0 mg/kg). Hyperactivity was related to a linear increase in whole brain concentrations of DMT as measured by a new sensitive gas chromatographic assay. The duration of this behaviour paralleled the concentration of DMT in the brain from 15–120 min. However, at 15 min, there was no significant difference in brain… 

References

SHOWING 1-10 OF 30 REFERENCES

Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats

Hallucinogenic drugs of the indolealkylamine type and central monoamine neurons.

Findings indicate a 5-HT receptor stimulation by psilocybin and dimethyltryptamine in the same way as has previously been found for d -lysergic acid diethylamide (LSD), since the effects were independent of the known stores of5-HT.

Accumulation of N,N-dimethyltryptamine in rat brain cortical slices.

In general, irrespective of pharmacologic class, the tertiary amines were more potent than the secondary or primary amines, although there were some exceptions.

Biphasic dose-response effects of N-N-dimethyltryptamine on the rat startle reflex.

Tryptamine-N-methyltransferase activity in brain tissue: a re-examination

THE DISTRIBUTION AND PROPERTIES OF THE NONSPECIFIC N‐METHYLTRANSFERASE IN BRAIN

Enzymatic activity is unevenly distributed in the brain with the highest activity in the cerebral cortex and striaturn of the rat and in the subcortical white matter in man.

LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE

The results fail to support the hypothesis that psychotropic effects of methionine or SAMe are due to increased accumulations of pharmacologically active methylated indoleamines, and the production of [14]DMT was instead markedly irihihitrd by this treatment.

The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine.

The authors review the research on DMT as a possible "schizotoxin" and conclude that more data are necessary before the validity of this theory can be determined.