Effects of parathyroid hormone on Wnt signaling pathway in bone.

  title={Effects of parathyroid hormone on Wnt signaling pathway in bone.},
  author={Nalini H Kulkarni and David L. Halladay and Rebecca R. Miles and Lindsay M Gilbert and Charles A. Frolik and Rachelle J Sells Galvin and Thomas J Martin and Matthew T. Gillespie and Jude E. Onyia},
  journal={Journal of cellular biochemistry},
  volume={95 6},
The Wnt signaling pathway has recently been demonstrated to play an important role in bone cell function. In previous studies using DNA microarray analyses, we observed a change in some of the molecular components of the canonical Wnt pathway namely, frizzled-1 (FZD-1) and axil, in response to continuous parathyroid hormone (PTH) treatment in rats. In the present study, we further explored other components of the Wnt signaling pathway in rat distal metaphyseal bone in vivo, and rat osteoblastic… CONTINUE READING


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