Effects of palytoxin on isolated intestinal and vascular smooth muscles.

@article{Ito1976EffectsOP,
  title={Effects of palytoxin on isolated intestinal and vascular smooth muscles.},
  author={Kiyotaka Ito and Hideaki Karaki and Yukio Ishida and Norimoto Urakawa and Takehiko Deguchi},
  journal={Japanese journal of pharmacology},
  year={1976},
  volume={26 6},
  pages={683-92}
}
Palytoxin (PTX), the most potent marine toxin isolated from the Zoanthid, Palythoa tuberculosa, was studied to determine the effect on isolated smooth muscles. In guinea pig taenia coli PTX at above 3 X 10(-10) g/ml caused a contraction which slowly subsided under isotonic recording. Under isometric recording PTX at above 1 X 10(-10) g/ml caused a contraction which depended on the spontaneous activity. The PTX-induced contraction was not affected by atropine, tripelenmamine or tetrodotoxin but… CONTINUE READING
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