Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
@article{Esposito2011EffectsOP, title={Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury}, author={Emanuela Esposito and Irene Paterniti and Emanuela Mazzon and Tiziana Genovese and Rosanna Di Paola and Maria Galuppo and Salvatore Cuzzocrea}, journal={Brain, Behavior, and Immunity}, year={2011}, volume={25}, pages={1099-1112} }
89 Citations
Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries.
- BiologyCNS & neurological disorders drug targets
- 2013
An overview of current knowledge of PEA effect on glial functions in the brain and how targeting glial-specific pathways might ultimately impact the development of therapies for clinical management of neurodegenerative disorders is provided.
Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice
- BiologyBrain, Behavior, and Immunity
- 2012
The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury
- BiologyMolecular Neurobiology
- 2015
Results showed that treatment with co-ultraPEALut after SCI reduced the expression of proteins promoter of autophagy such as Beclin-1 and microtubule-associated protein 1A/1B-light chain 3 (MAP-LC3) and could be considered as a possible therapeutic approach in an acute traumatic lesion like SCI.
The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice
- Biology, MedicinePloS one
- 2019
Data show the protective roles of adelmidrol + sodium hyaluronate on bladder following SCI, highlighting a potential therapeutic target for the reduction of bladder changes.
The neuroprotective effects of micronized PEA (PEA‐m) formulation on diabetic peripheral neuropathy in mice
- BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2019
It is demonstrated that PEA‐m represents a new therapeutic strategy for neuroinflammation pain associated with mixed neuropathies and could be correlated at least in part to peroxisome proliferator‐activated receptor‐α activation.
A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
- BiologyJournal of Neuroinflammation
- 2013
The present study demonstrates that the protective effect of PEA on SCI-associated neuroinflammation could be improved by co-ultramicronization with Lut possibly due to its antioxidant properties.
Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury
- BiologyFront. Pharmacol.
- 2016
Findings show a prominent effect of co-ultraPEALut administration in the management of survival and differentiation of new neurons and spine maturation, and may represent a therapeutic treatment for spinal cord and other traumatic diseases.
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia
- BiologyBrain Research
- 2016
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution
- BiologyMolecular Neurobiology
- 2015
The role of mast cells and glia in neuroinflammation and strategies to modulate their activation based on leveraging natural mechanisms with the capacity for self-defense against inflammation are discussed.
Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide.
- BiologyCNS & neurological disorders drug targets
- 2013
The data show that PEA delayed mast cell recruitment, protected mast cells against degranulation and abolished the nerve growth factor increase in sciatic nerve concomitantly preserving the nerve from degeneration, while reducing microglia activation in the spinal cord.
References
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