Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering.

@article{Kurata2007EffectsOP,
  title={Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering.},
  author={Yasutaka Kurata and Hiroyuki Matsuda and Ichiro Hisatome and Toshishige Shibamoto},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 1},
  pages={H701-18}
}
A cardiac biological pacemaker (BP) has been created by suppression of the inward rectifier K(+) current (I(K1)) or overexpression of the hyperpolarization-activated current (I(h)). We theoretically investigated the effects of incorporating I(h), T-type Ca(2+) current (I(Ca,T)), sustained inward current (I(st)), and/or low-voltage-activated L-type Ca(2+) channel current (I(Ca,LD)) on 1) creation of BP cells, 2) robustness of BP activity to electrotonic loads of nonpacemaking (NP) cells, and 3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Expression and function of a biological pacemaker in canine heart

  • J Qu, AN Plotnikov, +4 authors MR. Rosen
  • Circulation 107:
  • 2003
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…