Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins.

@article{Lindn2004EffectsOP,
  title={Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins.},
  author={Sara Lind{\'e}n and Jafar Mahdavi and Jan Hedenbro and Thomas Bor{\'e}n and Ingemar Carlstedt},
  journal={The Biochemical journal},
  year={2004},
  volume={384 Pt 2},
  pages={
          263-70
        }
}
Helicobacter pylori causes gastritis, peptic ulcer disease and gastric cancer. The microbe is found in the gastric mucus layer where a pH gradient ranging from acidic in the lumen to neutral at the cell surface is maintained. The aim of the present study was to investigate the effects of pH on H. pylori binding to gastric mucins from healthy individuals. At pH 3, all strains bound to the most charged MUC5AC glycoform and to a putative mucin of higher charge and larger size than subunits of… CONTINUE READING

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