Effects of pH changes on calcium-mediated potentials in rat hippocampal neurons in vitro.

The effects of changes in extra- and intracellular pH (pHo and pHi, respectively) on potentials mediated by the influx of Ca2+ ions were investigated in intracellular "current-clamp" recordings from CA1 pyramidal neurons in rat hippocampal slices. In neurons which exhibited a "regular-spiking" discharge in response to depolarizing current injection at pH 7… (More)