Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

@article{Forrester1995EffectsOP,
  title={Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.},
  author={Kathleen S Forrester and Shawn E Lupold and Vanessa L. Ott and Christopher H Chay and Vimla Band and Xin Wei Wang and Curtis C. Harris},
  journal={Oncogene},
  year={1995},
  volume={10 11},
  pages={2103-11}
}
The spectrum of p53 mutations differs among human cancer types. We have hypothesized that the p53 mutational spectrum observed in particular tumor types reflects the functional ability of different p53 mutants to modulate wild-type (WT) p53-dependent gene transcription. Missense p53 mutants representing several mutational hotspot codons were cotransfected with WT p53 and analysed for their effects on p53-dependent transactivation of a reporter construct containing a specific p53 binding… CONTINUE READING