Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.

  title={Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.},
  author={Yunpeng Du and Jie-long Tang and Guangyuan Li and Liliana N. Berti-Mattera and CHIEH-ALLEN Lee and Darian M Bartkowski and David C. Gale and Joseph B. Monahan and Michael R. Niesman and Gordon R Alton and Timothy S. Kern},
  journal={Investigative ophthalmology \& visual science},
  volume={51 4},
Purpose. p38 mitogen-activated protein kinase (MAPK) is known to play a regulatory role in inflammatory processes in disease. Inflammation has been linked also to the development of diabetic retinopathy in rodents. This study was conducted to evaluate the effect of a p38 MAPK inhibitor on the development of early stages of diabetic retinopathy in rats. Methods. Streptozotocin-diabetic rats were assigned to two groups-treated with the p38 MAPK inhibitor PHA666859 (Pfizer, New York, NY) and… 

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