Effects of ozone exposure on nonspecific phagocytic capacity of pulmonary macrophages from an amphibian, Bufo marinus

  title={Effects of ozone exposure on nonspecific phagocytic capacity of pulmonary macrophages from an amphibian, Bufo marinus},
  author={Michael R. Dohm and William J. Mautz and Joy A. Andrade and Kapuaola S. Gellert and Loney J. Salas‐Ferguson and Nicola Nicolaisen and Nicole Fujie},
  journal={Environmental Toxicology and Chemistry},
Pulmonary macrophages are an important component of immune defense against inhaled foreign particles and microorganisms. In humans and other mammals, exposure to moderate amounts of ozone (O3) can inhibit functional capacities of alveolar macrophages. In many wilderness areas downwind of urban centers, ozone levels frequently exceed national standards. We report results of 4‐h inhalation exposures to 0.8 parts per million O3 on pulmonary macrophage viability and phagocytosis capacity in marine… 

Ozone exposure affects feeding and locomotor behavior of adult Bufo marinus

It is suggested that a single 4‐h exposure to O3 depresses toad feeding behavior after exposure but had little effect on voluntary locomotor behavior.

Optimizing Studies of Phagocytic Activity by Flowsight Cytometry in Amphibians

It is worth highlighting the importance of morphologically identifying the cells and evaluating the number of internalized particles by flowsight cytometry, a valuable asset to further explore phagocytosis and other cellular processes in amphibians under field and laboratory conditions.

Increased tropospheric ozone levels enhance pathogen infection levels of amphibians.

Captivity effects on immune response and steroid plasma levels of a Brazilian toad (Rhinella schneideri)

Phagocytosis efficiency was positively associated with T and body condition, suggesting that the effects of chronic stress on reproductive potential and immune response might be associated with the state of energetic reserves.

Acute effects of ambient ozone on daily hospital admissions and daily mortality for respiratory and cardiovascular diseases among residents of Bangkok, Thailand

Daily O3 concentrations were positively associated with daily mortality from cardiovascular diseases among both all-age group and the 55-79 age group, but this association was not significant.

Calling rate, corticosterone plasma levels and immunocompetence of Hypsiboas albopunctatus.



Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure.

Comparison of the PAM population doubling time (Dt) and cell cycle time (Ct) suggest that PAM proliferation played a significant role in the observed increase in PAM following exposure to 0.8 and 1.5 ppm O3.

Effects of pollutant atmospheres on surface receptors of pulmonary macrophages.

The decrease in phagocytosis and inhibition of FcR of macrophages suggests an impairment ofmacrophage function that probably renders the host vulnerable to bacterial and/or viral infections.

Ozone-enhanced pulmonary infection with Streptococcus zooepidemicus in mice. The role of alveolar macrophage function and capsular virulence factors.

It is demonstrated that O3 inhalation impairs AM activity in the lung, and the streptococci are able to proliferate and more fully express virulence factors, in particular, the antiphagocytic capsule, which prohibits the ingestion of bacteria by pulmonary phagocytes and leads to increased severity of infection.

Enhanced phagocytosis by alveolar macrophages induced by short-term ozone insult.

Interspecies comparison of rat and hamster alveolar macrophage antioxidative and oxidative capacity.

The data suggest that species variation exists between the oxidative capacity of rat and that of hamster AM, and it is suggested that rat AM possess an additional oxidative system.

The alveolar macrophage.

  • D. Bowden
  • Medicine
    Environmental health perspectives
  • 1984
The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs, which involves interactions with fibroblastic cells and tissue injury initiated by proteases secreted by the macrophage.

Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture.

Progressively exacerbated breathing-pattern responses at high concentrations were associated with lung lesions and high cell-proliferation labeling in the nose transitional epithelium and terminal bronchioles.

Effects of ozone on evaporative water loss and thermoregulatory behavior of marine toads (Bufo marinus).

Ozone-exposed toads with higher evaporative water loss rates, in turn, also selected lower PBT, voluntary minimum, and voluntary maximum temperatures 24 h post-exposure, which may alter both water balance and thermal preferences in anuran amphibians.

Differential effects of temperature on macrophages of ectothermic vertebrates

The role of macrophages in vertebrate defense reactions is especially important at low temperatures, which commonly affect representatives of ectothermic species. The aim of this work was to compare