Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans.

@article{Adachi1998EffectsOO,
  title={Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans.},
  author={Hitoshi Adachi and Yuko Fujiwara and Naoaki Ishii},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={1998},
  volume={53 4},
  pages={B240-4}
}
Protein carbonyl accumulation is an indicator of oxidative damage during aging. The relationship between oxidative stress and protein carbonylation during aging was studied by using a long (age-1) and a short (mev-1) life span mutant of Caenorhabditis elegans. Protein carbonyl concentrations were similar in young adults of both mutants and wild type; however, the subsequent age-dependent accumulation was different with the genotype. The mev-1 mutant (with 50% superoxide dismutase activity… CONTINUE READING

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