Corpus ID: 11301972

Effects of oxidizing and reducing analogs of acetylcholine on neuronal nicotinic receptors.

@article{Xie1992EffectsOO,
  title={Effects of oxidizing and reducing analogs of acetylcholine on neuronal nicotinic receptors.},
  author={Y. Xie and G. Jones and R. Loring},
  journal={Molecular pharmacology},
  year={1992},
  volume={42 2},
  pages={
          356-63
        }
}
  • Y. Xie, G. Jones, R. Loring
  • Published 1992
  • Chemistry, Medicine
  • Molecular pharmacology
  • The synthesis and pharmacological characterization of dithiobisacetylcholine and dithiobis-N,N-dimethyl-4-acetylpiperazinium (two oxidizing analogs of acetylcholine), as well as those of their reduced counterparts, are described. Both the oxidizing and reducing analogs stimulate nicotinic receptors in the chick retina and block the binding of 125I-labeled neuronal bungarotoxin to retinal homogenates (IC50 values of 2 x 10(-6) to 6 x 10(-5) M). Both oxidizing compounds reverse the physiological… CONTINUE READING
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