Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis.

@article{Cox1996EffectsOO,
  title={Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis.},
  author={David A. Cox and Marlene L. Cohen},
  journal={Pharmacological reviews},
  year={1996},
  volume={48 1},
  pages={
          3-19
        }
}
Oxidized LDL exerts profound effects on the vasomotor response of isolated blood vessels to various stimuli that closely mimic the vascular dysfunction associated with hypercholesterolemia and atherosclerosis in humans. The beneficial effect of lipid-lowering therapy in normalizing vascular function and greatly decreasing the frequency of clinical events associated with atherosclerosis, combined with the ability of antioxidants to alleviate vasomotor disturbances in hypercholesterolemia and… CONTINUE READING

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