Effects of oxidative challenge and calcium on ATP-levels in neuronal cells.

@article{Teepker2007EffectsOO,
  title={Effects of oxidative challenge and calcium on ATP-levels in neuronal cells.},
  author={Michael Teepker and N. Anthes and Sabine Fischer and J{\"u}rgen-Christian Krieg and Helmut Vedder},
  journal={Neurotoxicology},
  year={2007},
  volume={28 1},
  pages={19-26}
}
BACKGROUND Neurocellular overload with hydrogen peroxide (H2O2) induces oxidative stress and may initiate a cascade of intracellular toxic events leading to energy failure, increased lipid peroxidation and subsequently cell death. Studies suggest that hippocampal neurons may be more vulnerable to oxidative stress than cortical cells pointing to a differential vulnerability of neuronal cells. Since disturbed ATP- and calcium (Ca2+)-metabolism may be involved in this process, we here evaluated… CONTINUE READING