Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.

@article{Norris2003EffectsOO,
  title={Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.},
  author={Erin H. Norris and Benoit I Giasson and Harry Ischiropoulos and Virginia M-Y Lee},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 29},
  pages={27230-40}
}
Filamentous inclusions of alpha-synuclein protein are hallmarks of neurodegenerative diseases collectively known as synucleinopathies. Previous studies have shown that exposure to oxidative and nitrative species stabilizes alpha-synuclein filaments in vitro, and this stabilization may be due to dityrosine cross-linking. To test this hypothesis, we mutated tyrosine residues to phenylalanine and generated recombinant wild type and mutant alpha-synuclein proteins. alpha-Synuclein proteins lacking… CONTINUE READING

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