Effects of oxicam inhibitors of cyclooxygenase on oxidative stress generation in rat gastric mucosa. A comparative study.

@article{Villegas2002EffectsOO,
  title={Effects of oxicam inhibitors of cyclooxygenase on oxidative stress generation in rat gastric mucosa. A comparative study.},
  author={Isabel Villegas and Mar{\'i}a J. Mart{\'i}n and Carmen La Casa and Virginia Motilva and Catalina Alarc{\'o}n de la Lastra},
  journal={Free radical research},
  year={2002},
  volume={36 7},
  pages={769-77}
}
The aim of this study was to compare the effects of two nonsteroidal anti-inflammatory drugs (NSAID), members of the same family with a different cyclooxygenase (COX) inhibition selectivity, meloxicam, preferent COX-2 inhibitor, and piroxicam, preferent COX-1 inhibitor, on oxygen radical generation in rat gastric mucosa. Therefore, the activity of oxidative stress-related enzymes such as xanthine oxidase (XO), superoxide dismutase (SOD) and glutathione (GSH) homeostasis were studied in rats… CONTINUE READING

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