Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes.

@article{Yao1998EffectsOO,
  title={Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes.},
  author={Atsushi Yao and Zhi Su and Akihiko Nonaka and Iram Zubair and Liyan Lu and Kenneth D. Philipson and John H. B. Bridge and William H. Barry},
  journal={Circulation research},
  year={1998},
  volume={82 6},
  pages={657-65}
}
We measured [Ca2+]i and [Na+]i in isolated transgenic (TG) mouse myocytes overexpressing the Na+-Ca2+ exchanger and in wild-type (WT) myocytes. In TG myocytes, the peak systolic level and amplitude of electrically stimulated (ES) [Ca2+]i transients (0.25 Hz) were not significantly different from those in WT myocytes, but the time to peak [Ca2+]i was significantly prolonged. The decline of ES [Ca2+]i transients was significantly accelerated in TG myocytes. The decline of a long-duration (4-s… CONTINUE READING
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