Effects of ovariectomy on the changes in microarchitecture and material level properties in response to hind leg disuse in female rats.

@article{Mamoun2012EffectsOO,
  title={Effects of ovariectomy on the changes in microarchitecture and material level properties in response to hind leg disuse in female rats.},
  author={Laurent Ma{\"i}moun and Tara C. Brennan-Speranza and Ren{\'e} R Rizzoli and Patrick Ammann},
  journal={Bone},
  year={2012},
  volume={51 3},
  pages={586-91}
}
BACKGROUND Ovariectomy (OVX) and immobilization are known to decrease bone mineral density and alter its microarchitecture. Their effects on the material level properties of bone, a determinant of bone strength, are still largely unknown. We investigated the effect of OVX and/or disuse achieved by sciatic neurectomy (NX) in 6-month-old Sprague Dawley female rats. METHODS At baseline, animals underwent OVX or sham operation. At week 16, NX was performed on the left hindlimb while the right… CONTINUE READING