Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.

@article{Carbone1992EffectsOO,
  title={Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.},
  author={Silvia Carbone and Berta Szwarcfarb and Matilde E. Otero Losada and Jaime A. Moguilevsky},
  journal={Endocrinology},
  year={1992},
  volume={130 3},
  pages={
          1365-70
        }
}
In order to evaluate the involvement of estrogen-progesterone (EP) in the effects of N-methyl-D-aspartate (NMDA) receptor stimulation on gonadotropin secretion during sexual development in female rats, NMDA (30 mg/kg sc) was administered to 16- and 30-day-old female rats pretreated with EP. NMDA administration induced increases in plasma LH concentration that were 13.6-fold and 94.5-fold higher, respectively, than those found after NMDA alone. The increase of LH levels induced by NMDA was… 
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TLDR
The purpose of the present experiment was to determine whether this effect of photoperiod on LH response toNMDA is mediated by melatonin and whether it reflects a change in the amount of LHRH released in response to NMDA.
Sexual differences in the role of kainate receptors in controlling gonadotrophin secretion in prepubertal rats.
TLDR
The results indicate that the role of kainate receptors in the control of gonadotrophin secretion is sexually dimorphic around puberty, since: (a) LH secretion was stimulated by kainic acid in male rats but inhibited in females; (b) FSH secretion was inhibited by kainsate acid in ovariectomized females, but not in orchidECTomized males; and (c) DNQX inhibited LH secretion in males but notIn females.
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TLDR
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