Effects of ovarian hormones on human cortical excitability

  title={Effects of ovarian hormones on human cortical excitability},
  author={Mark J. Smith and Linda F. Adams and Peter J. Schmidt and David R Rubinow and Eric M. Wassermann},
  journal={Annals of neurology},
  volume={51 5},
Ovarian steroids appear to alter neuronal function in women, but direct physiological evidence is lacking. In animals, estradiol enhances excitatory neurotransmission. Progesterone-derived neurosteroids increase GABAergic inhibition. The effect of weak transcranial magnetic stimulation of the motor cortex on the motor evoked potential (MEP) from transcranial magnetic stimulation given milliseconds later is changed by GABAergic and glutamatergic agents. Using this technique previously, we showed… CONTINUE READING


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