Effects of orthotopic heart transplantation on sympathetic control mechanisms in congestive heart failure.

@article{Levine1986EffectsOO,
  title={Effects of orthotopic heart transplantation on sympathetic control mechanisms in congestive heart failure.},
  author={T. Barry Levine and Maria Teresa Olivari and Jay N. Cohn},
  journal={The American journal of cardiology},
  year={1986},
  volume={58 10},
  pages={1035-40}
}
Abnormal sympathetic nervous system activity in severe congestive heart failure (CHF) was studied in 14 patients before and 3 to 6 months after orthotopic heart transplantation. Before transplantation plasma norepinephrine (NE) levels at rest were elevated (909 +/- 429 pg/ml, p less than 0.01 compared with normal, 185 +/- 60 pg/ml). No reflex activation of the sympathetic nervous system was seen with infusion of sodium nitroprusside despite a significant decrease in arterial pressure. The… CONTINUE READING