Effects of organophosphorus anticholinesterases on nicotinic receptor ion channels at adult mouse muscle endplates.

@article{Tattersall1990EffectsOO,
  title={Effects of organophosphorus anticholinesterases on nicotinic receptor ion channels at adult mouse muscle endplates.},
  author={John E. H. Tattersall},
  journal={British journal of pharmacology},
  year={1990},
  volume={101 2},
  pages={349-57}
}
1. The effects of a range of organophosphorus anticholinesterases on the nicotinic acetylcholine receptor ion channel at the adult mouse muscle endplate were investigated by use of single-channel recording techniques. Diisopropylfluorophosphate (DFP), sarin and soman had no effect on open times at concentrations of up to 100 microM, but ecothiopate (Eco) and O-ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate (VX) were found to have voltage- and concentration-dependent open channel… CONTINUE READING

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It is concluded that the direct actions of organophosphates on nicotinic receptor ion channels are of little importance for their toxicity under normal conditions , since they occur only at much higher concentrations than those which cause inhibition of acetylcholinesterase .
The effects of a range of organophosphorus anticholinesterases on the nicotinic acetylcholine receptor ion channel at the adult mouse muscle endplate were investigated by use of single - channel recording techniques .
It is concluded that the direct actions of organophosphates on nicotinic receptor ion channels are of little importance for their toxicity under normal conditions , since they occur only at much higher concentrations than those which cause inhibition of acetylcholinesterase .
The effects of a range of organophosphorus anticholinesterases on the nicotinic acetylcholine receptor ion channel at the adult mouse muscle endplate were investigated by use of single - channel recording techniques .
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
It is concluded that the direct actions of organophosphates on nicotinic receptor ion channels are of little importance for their toxicity under normal conditions , since they occur only at much higher concentrations than those which cause inhibition of acetylcholinesterase .
The effects of a range of organophosphorus anticholinesterases on the nicotinic acetylcholine receptor ion channel at the adult mouse muscle endplate were investigated by use of single - channel recording techniques .
It is concluded that the direct actions of organophosphates on nicotinic receptor ion channels are of little importance for their toxicity under normal conditions , since they occur only at much higher concentrations than those which cause inhibition of acetylcholinesterase .
The effects of a range of organophosphorus anticholinesterases on the nicotinic acetylcholine receptor ion channel at the adult mouse muscle endplate were investigated by use of single - channel recording techniques .
SarinNo subtypeSoman
Sarin and soman both increased the rate of this decline , indicating that they accelerated the rate of desensitization of the receptors .
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
SomanNo subtypeSarin
Diisopropylfluorophosphate ( DFP ) , sarin and soman had no effect on open times at concentrations of up to 100 microM , but ecothiopate ( Eco ) and O - ethyl S-[2-(diisopropylamino)ethyl]methyl phosphonothiolate ( VX ) were found to have voltage- and concentration - dependent open channel - blocking actions at concentrations of 1 - 50 microM.
Sarin and soman both increased the rate of this decline , indicating that they accelerated the rate of desensitization of the receptors .
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