Effects of oral preload, CCK or bombesin administration on short term food intake of melanocortin 4-receptor knockout (MC4RKO) mice.

@article{Vaughan2006EffectsOO,
  title={Effects of oral preload, CCK or bombesin administration on short term food intake of melanocortin 4-receptor knockout (MC4RKO) mice.},
  author={Cheryl H Vaughan and Carrie Haskell-Luevano and Amy M Andreasen and Neil E. Rowland},
  journal={Peptides},
  year={2006},
  volume={27 12},
  pages={3226-33}
}
We investigated whether either heterozygous (HET) or homozygous (knockout, KO) disruption of the melanocortin type 4 receptor (MC4R) gene alters post ingestive responsiveness of mice. Specifically, we tested the hypothesis that hyperphagia in MC4RKO mice might be due to a deficit in processes that sustain intermeal intervals (satiety) and/or processes that terminate ongoing episodes of eating (satiation). To test satiety, mice drank an oral preload and then we monitored intake of a subsequent… CONTINUE READING