Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.

@article{Whelton1997EffectsOO,
  title={Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.},
  author={Paul K. Whelton and J. He and Jeffrey A. Cutler and Frederick L. Brancati and Lawrence J. Appel and Dean A. Follmann and Michael John Klag},
  journal={JAMA},
  year={1997},
  volume={277 20},
  pages={
          1624-32
        }
}
OBJECTIVE To assess the effects of supplementation with oral potassium on blood pressure in humans. DESIGN Meta-analysis of randomized controlled trials. DATA SOURCES English-language articles published before July 1995. STUDY SELECTION Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only difference between the intervention and control conditions. DATA EXTRACTION Using a standardized protocol, 2 of us independently abstracted… Expand
Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials
TLDR
The findings indicated that potassium supplementation is a safe medication with no important adverse effects that has a modest but significant impact BP and may be recommended as an adjuvant antihypertensive agent for patients with essential hypertension. Expand
Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo-controlled trial
TLDR
The data indicate that moderate potassium supplementation resulted in a substantial reduction in systolic BP, and suggest that increased potassium intake may play an important role in the prevention and treatment of hypertension in China. Expand
Potassium supplementation for the management of primary hypertension in adults.
TLDR
This systematic review found no statistically significant effect of potassium supplementation on blood pressure and suggested that further high quality RCTs of longer duration are required to clarify whether potassium supplementation can reduce blood Pressure and improve health outcomes. Expand
The effect of low-dose potassium supplementation on blood pressure in apparently healthy volunteers
TLDR
A low daily dietary supplement of K, equivalent to the content of five portions of fresh fruits and vegetables, induced a substantial reduction in mean arterial pressure, similar in effect to single-drug therapy for hypertension. Expand
Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials.
TLDR
Increasing the intake of fiber in Western populations, where intake is far below recommended levels, may contribute to the prevention of hypertension. Expand
Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
TLDR
It is suggested that alcohol reduction should be recommended as an important component of lifestyle modification for the prevention and treatment of hypertension among heavy drinkers. Expand
Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses
TLDR
High quality evidence shows that increased potassium intake reduces blood pressure in people with hypertension and has no adverse effect on blood lipid concentrations, catecholamine concentrations, or renal function in adults in adults. Expand
Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials
TLDR
Patients with elevated blood pressure should follow a weight-reducing diet, take regular exercise, and restrict alcohol and salt intake, as available evidence does not support relaxation therapies, calcium, magnesium or potassium supplements to reduce blood pressure. Expand
Magnesium supplementation for the management of essential hypertension in adults.
TLDR
The evidence in favour of a causal association between magnesium supplementation and blood pressure reduction is weak and is probably due to bias because poor quality studies generally tend to over-estimate the effects of treatment. Expand
Potassium Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials
TLDR
An adequate intake of potassium is desirable to achieve a lower BP level but excessive potassium supplementation should be avoided, particularly in specific subgroups, according to the findings of a meta‐analysis. Expand
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References

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Does potassium supplementation lower blood pressure? A meta-analysis of published trials.
TLDR
An increase in potassium intake should be included in the recommendations for a non-pharmacological approach to the control of blood pressure in uncomplicated essential hypertension. Expand
Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. A randomized, double-blind, placebo-controlled trial.
TLDR
Potassium supplementation reduces blood pressure substantially in African Americans consuming a diet low in potassium, and increased potassium intake may play an important role in reducing blood pressure in this population at high risk for hypertension. Expand
Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension.
TLDR
In conclusion, 120 mEq/day of microencapsulated potassium chloride was well tolerated in adults with mild hypertension and an antihypertensive effect of potassium cannot be ruled out despite the fact that there was no statistically significant difference between potassium-treated and placebo-treated subjects. Expand
The effect of potassium supplementation in persons with a high-normal blood pressure. Results from phase I of the Trials of Hypertension Prevention (TOHP). Trials of Hypertension Prevention (TOHP) Collaborative Research Group.
TLDR
There was a significant, independent, dose-response relationship between change in both 24-hour urinary potassium excretion and urinary sodium-potassium ratio and the corresponding change in diastolic blood pressure and the highest versus the lowest quartile of change in urinaryassium excretion. Expand
Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study.
TLDR
Potassium 60 mmol/day lowers arterial blood pressure in patients with mild hypertension and giving magnesium as well has no added advantage. Expand
Effect of potassium supplementation combined with dietary sodium reduction on blood pressure in men taking antihypertensive medication
  • R. Grimm, P. Kofron, +6 authors R. Prineas
  • Medicine
  • Journal of hypertension. Supplement : official journal of the International Society of Hypertension
  • 1988
TLDR
The Minnesota Mount Sinai Hypertension Trial (MSHT) is a double-blind study comparing placebo with potassium supplementation for controlling blood pressure in hypertensive men on a sodium-restricted diet over a 2–3 year follow-up period. Expand
Controlled trial of long term oral potassium supplements in patients with mild hypertension.
TLDR
Results show that moderate oral potassium supplements are associated with a long term reduction in blood pressure in patients who have mild hypertension. Expand
Blood pressure response to potassium supplementation in normotensive adults and children.
TLDR
It is suggested that increasing intake of dietary potassium alone in a healthy, free-living normotensive population is unlikely to have a discernible effect on blood pressure. Expand
Placebo-controlled trial of potassium supplements in black patients with mild essential hypertension
TLDR
Results from a double-blind clinical trial of the efficacy and tolerability of oral potassium supplements versus a matching placebo are consistent with the premise that oralassium supplements may exert hypotensive effects of clinically significant degree in patients with mild hypertension. Expand
Increasing the dietary potassium intake reduces the need for antihypertensive medication.
TLDR
Increasing the dietary potassium intake from natural foods is a feasible and effective measure to reduce antihypertensive drug treatment. Expand
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