Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.

  title={Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials.},
  author={Paul K. Whelton and J. He and Jeffrey A. Cutler and Frederick L. Brancati and Lawrence J. Appel and Dean A. Follmann and Michael John Klag},
  volume={277 20},
OBJECTIVE To assess the effects of supplementation with oral potassium on blood pressure in humans. DESIGN Meta-analysis of randomized controlled trials. DATA SOURCES English-language articles published before July 1995. STUDY SELECTION Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only difference between the intervention and control conditions. DATA EXTRACTION Using a standardized protocol, 2 of us independently abstracted… 

Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials

The findings indicated that potassium supplementation is a safe medication with no important adverse effects that has a modest but significant impact BP and may be recommended as an adjuvant antihypertensive agent for patients with essential hypertension.

Potassium supplementation for the management of primary hypertension in adults.

This systematic review found no statistically significant effect of potassium supplementation on blood pressure and suggested that further high quality RCTs of longer duration are required to clarify whether potassium supplementation can reduce blood Pressure and improve health outcomes.

The effect of low-dose potassium supplementation on blood pressure in apparently healthy volunteers

A low daily dietary supplement of K, equivalent to the content of five portions of fresh fruits and vegetables, induced a substantial reduction in mean arterial pressure, similar in effect to single-drug therapy for hypertension.

Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

It is suggested that alcohol reduction should be recommended as an important component of lifestyle modification for the prevention and treatment of hypertension among heavy drinkers.

Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses

High quality evidence shows that increased potassium intake reduces blood pressure in people with hypertension and has no adverse effect on blood lipid concentrations, catecholamine concentrations, or renal function in adults in adults.

Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials

Patients with elevated blood pressure should follow a weight-reducing diet, take regular exercise, and restrict alcohol and salt intake, as available evidence does not support relaxation therapies, calcium, magnesium or potassium supplements to reduce blood pressure.

Magnesium supplementation for the management of essential hypertension in adults.

The evidence in favour of a causal association between magnesium supplementation and blood pressure reduction is weak and is probably due to bias because poor quality studies generally tend to over-estimate the effects of treatment.

Potassium Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials

An adequate intake of potassium is desirable to achieve a lower BP level but excessive potassium supplementation should be avoided, particularly in specific subgroups, according to the findings of a meta‐analysis.

Daily potassium intake and sodium-to-potassium ratio in the reduction of blood pressure: a meta-analysis of randomized controlled trials

Potassium supplementation is associated with reduction of blood pressure in patients who are not on antihypertensive medication, and the effect is significant in hypertensive patients.



Does potassium supplementation lower blood pressure? A meta-analysis of published trials.

An increase in potassium intake should be included in the recommendations for a non-pharmacological approach to the control of blood pressure in uncomplicated essential hypertension.

Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. A randomized, double-blind, placebo-controlled trial.

Potassium supplementation reduces blood pressure substantially in African Americans consuming a diet low in potassium, and increased potassium intake may play an important role in reducing blood pressure in this population at high risk for hypertension.

Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension.

In conclusion, 120 mEq/day of microencapsulated potassium chloride was well tolerated in adults with mild hypertension and an antihypertensive effect of potassium cannot be ruled out despite the fact that there was no statistically significant difference between potassium-treated and placebo-treated subjects.

Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo controlled, crossover study.

Potassium 60 mmol/day lowers arterial blood pressure in patients with mild hypertension and giving magnesium as well has no added advantage.

Effect of potassium supplementation combined with dietary sodium reduction on blood pressure in men taking antihypertensive medication

  • R. GrimmP. Kofron R. Prineas
  • Medicine
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension
  • 1988
The Minnesota Mount Sinai Hypertension Trial (MSHT) is a double-blind study comparing placebo with potassium supplementation for controlling blood pressure in hypertensive men on a sodium-restricted diet over a 2–3 year follow-up period.

Controlled trial of long term oral potassium supplements in patients with mild hypertension.

Results show that moderate oral potassium supplements are associated with a long term reduction in blood pressure in patients who have mild hypertension.

Blood pressure response to potassium supplementation in normotensive adults and children.

It is suggested that increasing intake of dietary potassium alone in a healthy, free-living normotensive population is unlikely to have a discernible effect on blood pressure.

Increasing the dietary potassium intake reduces the need for antihypertensive medication.

Increasing the dietary potassium intake from natural foods is a feasible and effective measure to reduce antihypertensive drug treatment.

Effect of low sodium diet or potassium supplementation on adolescent blood pressure.

This study tested the feasibility of 3-year sodium reduction or potassium supplementation in adolescents and the effect of these interventions on the rate of rise of blood pressure during adolescence using a random-coefficient growth curve model.