Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects

@article{Ford2011EffectsOO,
  title={Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects},
  author={H. Ford and V. Peters and N. Martin and M. Sleeth and M. Ghatei and G. Frost and S. Bloom},
  journal={European Journal of Clinical Nutrition},
  year={2011},
  volume={65},
  pages={508-513}
}
Background/Objective:The sweet-taste receptor (T1r2+T1r3) is expressed by enteroendocrine L-cells throughout the gastrointestinal tract. Application of sucralose (a non-calorific, non-metabolisable sweetener) to L-cells in vitro stimulates glucagon-like peptide (GLP)-1 secretion, an effect that is inhibited with co-administration of a T1r2+T1r3 inhibitor. We conducted a randomised, single-blinded, crossover study in eight healthy subjects to investigate whether oral ingestion of sucralose could… Expand
Non-nutritive sweeteners and their role in the gastrointestinal tract.
Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion.
Addition of sucralose enhances the release of satiety hormones in combination with pea protein.
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References

SHOWING 1-10 OF 43 REFERENCES
Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects.
  • J. Ma, M. Bellon, +5 authors C. Rayner
  • Medicine, Chemistry
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2009
Cephalic phase responses to sweet taste.
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
Effect of peptide YY3-36 on food intake in humans.
Ingestion of Diet Soda Before a Glucose Load Augments Glucagon-Like Peptide-1 Secretion
Glucagon-like peptide-1: a potent regulator of food intake in humans
Sweet taste: Effect on cephalic phase insulin release in men
Attenuated peptide YY release in obese subjects is associated with reduced satiety.
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
Molecular mechanisms underlying nutrient-stimulated incretin secretion
...
1
2
3
4
5
...