Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers.

@article{Allen2011EffectsOO,
  title={Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers.},
  author={Jason Allen and Ryan D. Bradley},
  journal={Journal of alternative and complementary medicine},
  year={2011},
  volume={17 9},
  pages={
          827-33
        }
}
BACKGROUND The tripeptide glutathione (GSH) is the most abundant free radical scavenger synthesized endogenously in humans. Increasing mechanistic, clinical, and epidemiological evidence demonstrates that GSH status is significant in acute and chronic diseases. Despite ease of delivery, little controlled clinical research data exist evaluating the effects of oral GSH supplementation. OBJECTIVES The study objectives were to determine the effect of oral GSH supplementation on biomarkers of… 

Figures and Tables from this paper

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

These findings show, for the first time, that daily consumption of GSH supplements was effective at increasing body compartment stores of GSF in healthy adults.

A Review of Dietary (Phyto)Nutrients for Glutathione Support

Clinical evidence for nutritional strategies that could be used to improve glutathione status is explored, including amino acids, vitamins, minerals, phytochemicals, and foods can have important effects on circulating glutATHione which may translate to clinical benefit.

The Effect of Glutathione Supplementation (L-Glutation, Vitamin C, Alpha Lipoic Acid, and Zinc) on Total Antioxidant Status (TAS) Level -

This study shows that short term administration of antioxidant supplement containing glutathione, ascorbic acid, ALA, and zinc did not significantly affect the antioxidant level.

Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis

Glutathione (GSH) is a critical endogenous antioxidant found in all eukaryotic cells. Higher GSH concentrations protect against cellular damage, tissue degeneration, and disease progression in

Randomised clinical trial of long term glutathione supplementation offers protection from oxidative damage, improves HbA1c in elderly type 2 diabetic patients

GSH supplementation can be used as an adjunct therapy to anti-diabetic treatment to achieve better glycemic targets, especially in elderly population, as evidenced by a significant decrease in HbA1c and 8-OHdG and an increase in fasting insulin.

Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients

GSH supplementation caused a significant increase in blood GSH and helped maintain the baseline HbA1c overall and suggest GSH supplementation is of considerable benefit to patients above 55 years, not only supporting decreased glycated hemoglobin and fasting insulin but also increasing fasting insulin.

Dietary γ-Glutamylcysteine: Its Impact on Glutathione Status and Potential Health Outcomes

This commentary examines the classic biochemistry, toxicology, safety, and clinical value of GSH and its intermediates that may be modulated by dietary supplementation and some metabolic intermediates may function to preserve adequate GSH levels when the synthetic pathways decline in activity.

The absorptive effects of orobuccal non-liposomal nano-sized glutathione on blood glutathione parameters in healthy individuals: A pilot study

NLNG increased multiple blood glutathione parameters compared to placebo, and future research should examine whether NLNG can attenuate oxidative stress.

Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers

The pharmacokinetic profile of GSH in plasma after a single oral administration of SAG or GSH was described and SAG was not quantifiable in any plasma sample, suggesting that deacetylation of S AG occurs rapidly.
...

References

SHOWING 1-10 OF 37 REFERENCES

Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection.

OBJECTIVES To determine whether supplementation with alpha-lipoic acid (ALA), a glutathione-replenishing disulfide, modulates whole blood total glutathione (GSH + GSSG) levels and improves lymphocyte

The systemic availability of oral glutathione

It is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutATHione, suggesting that the systemic availability of glutathion is negligible in man.

Effect of orally administered glutathione on glutathione levels in some organs of rats: role of specific transporters

Analysis of data on absorption of orally administered glutathione (GSH) in rat jejunum and in other organs and the possible role of specific transport systems of GSH and γ-glutamyltranspeptidase indicated both these mechanisms seemed to be involved in increasing GSH content in heart after oral GSH administration.

Therapeutic potential of glutathione.

The modulation of GSH metabolism might present a useful adjuvant therapy in many pathologies such as intoxication, diabetes, uremia, sepsis, inflammatory lung processes, coronary disease, cancer and immunodeficiency states.

Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial.

This study provides evidence that GSH is a promising and effective new drug for the prevention of CDDP-induced neuropathy, and that it does not reduce the clinical activity of chemotherapeutic drugs.

8-OHdG in Cerebrospinal Fluid as a Marker of Oxidative Stress in Various Neurodegenerative Diseases

Higher CSF levels of 8-OHdG in non-demented PD patients as compared to the control group were observed, and could be potentially useful in the neurochemically supported diagnosis of PD.

Decreased synthetic capacity underlies the age-associated decline in glutathione content in Fisher 344 rats.

Although it is well documented that the concentration of glutathione (GSH), the most abundant intracellular free thiol and an important antioxidant, declines with age in many tissues of different

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes?

It is postulated that the association of serum GGT with type 2 diabetes reflects exposure to POPs, as these substances, which have a very long half-life, may influence diabetes risk by residing in adipose tissue as endocrine disruptors; and that POPs or similar substances may interact with obesity to cause type 1 diabetes.

The central role of glutathione in the pathophysiology of human diseases

The current state of knowledge on the role of GSH is reviewed to underscore its relevance in translational research for future therapeutic treatment design and to modulate redox-sensitive components of signal transduction cascades.