Effects of oral adsorbent AST-120 on the progression of chronic renal failure: a randomized controlled study.

Abstract

This prospective, randomized controlled study was designed to examine the effects of oral adsorbent AST-120 on the progression of chronic renal failure (CRF) in patients on a strict low protein diet (LPD). Twenty-six patients with CRF (serum creatinine 3.0 to 8.6 mg/dl) on a LPD were randomly assigned to a control group (N = 13) or an AST-120 group (N = 13). The 1/Cr slope and creatinine clearance (CCr) slope were used to estimate the progression rate of CRF; uremic toxins, serum and urinary indoxyl sulfate (IS), peak 2a and guanidino substrates (GS) measured by HPLC. Comparisons were made between the baseline observation period for 6 to 12 months and the treatment period (0.6 g/kg/day of LPD alone or concurrent with 6 g/day of AST-120, for the control and the AST-120 groups, respectively) for 12 to 24 months in both groups. Both the 1/Cr slope and CCr slope were significantly lessened in the treatment period only in the AST-120 group. Serum and urinary IS, but neither peak 2a nor GS were significantly decreased in the treatment period only in the AST-120 group. We conclude that AST-120 administration concurrent with LPD may be superior to LPD alone in retarding the progression of CRF by inhibiting accumulation of indoxyl sulfate.

0200400'02'04'06'08'10'12'14'16
Citations per Year

775 Citations

Semantic Scholar estimates that this publication has 775 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Owada1997EffectsOO, title={Effects of oral adsorbent AST-120 on the progression of chronic renal failure: a randomized controlled study.}, author={Akira Owada and Minoru Nakao and Junichi Koike and Kazutomo Ujiie and Kengo Tomita and Tatsuo Shiigai}, journal={Kidney international. Supplement}, year={1997}, volume={63}, pages={S188-90} }